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Patients receiving GLP1RAs, in particular, showed a reduction of 2.93 mg/dl in LDL-cholesterol levels and 5.52 mg/dl in total cholesterol levels with no conclusive effect in triglycerides or HDL-cholesterol
7 Compared to other antidiabetic drugs, GLP-1 RAs have the advantage of only being pharmacologically active when blood glucose levels are high
Before this approval, some doctors had prescribed Victoza off-label to support weight loss, reflecting the widespread use of GLP-1 drugs for managing body weight
Mounjaro, a newer option, is designed to tackle both diabetes management and weight loss simultaneously
The 6,300-patient study tested a once-monthly 15 mg dose of the anti-IL-6 drug, and while lab analyses showed it was acting as expected on the IL-6 pathway, it did not translate into clinical benefit
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