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According to NICE CKS Palpitations, ambulatory ECG monitoring should be selected based on symptom frequency: a 2448 hour Holter monitor is appropriate if palpitations occur daily, whilst a longer-wear patch monitor (714 days) or an event recorder is more suitable for less frequent episodes

In the phase 2 trial, the 8mg group achieved approximately 17.3% weight reduction at 24 weeks, a rate of loss that would not be possible without profound appetite suppression driving significant caloric deficit

The pathophysiology of PBH is complex and multifactorial

The half-life is approximately 7 days, enabling once-weekly injection

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