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complex carbs + healthy fats) Plenty of water (23L/day as appropriate), plus fiber/electrolytes for GI comfort GLP-1s are not the finish linehabits are

When IGF-1 binds to its receptor on muscle cells, it activates signaling pathways that promote protein synthesis and inhibit protein breakdown

Dr Paramesh Shamanna #Diabetes #Type2Diabetes #GLP1 #Tirzepatide #Semaglutide #Obesity #MetabolicHealth #Endocrinology #CGM #DiabetesRemission #Cardiometabolic To view or add a comment, sign in More Relevant Posts Day 49 / 365 Medicine of the Day: Rosuvastatin Drug Class: Statin (HMG-CoA Reductase Inhibitor) Lipid-lowering agent Indications / Uses: Hypercholesterolemia ( LDL-C) Mixed dyslipidemia Hypertriglyceridemia Prevention of cardiovascular events (MI, stroke) Familial hypercholesterolemia Mechanism of Action (MOA): Rosuvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in hepatic cholesterol synthesis Cholesterol production in liver LDL cholesterol & triglycerides HDL cholesterol LDL receptor expression increased LDL clearance Dose: Usual starting: 1020 mg once daily Maintenance: 540 mg once daily Severe hypercholesterolemia: up to 40 mg/day Renal impairment: lower starting dose recommended Adverse Effects: Myalgia / muscle pain Elevated liver enzymes Headache Nausea Risk of rhabdomyolysis (rare) Slight increase in blood glucose Drug Interactions: Cyclosporine rosuvastatin levels Gemfibrozil risk of myopathy Warfarin anticoagulant effect Antacids (Al/Mg) absorption Protease inhibitors statin toxicity risk Contraindications: Active liver disease Pregnancy Breastfeeding Hypersensitivity Clinical Pearl: Rosuvastatin is one of the most potent statins with strong LDL-lowering ability and proven cardiovascular risk reduction, often effective at lower doses compared to other statins

Ranjan A, Ramachandran S, Gupta N, Kaushik I, Wright S, Srivastava S, et al

GLP-1s can serve as a powerful complement to better lifestyle habits