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Given the rapid and increasing uptake of GLP1Ra-based therapies, coupled with the knowledge gap surrounding their impact on clinically relevant bone outcomes in older adults, we conducted an exploratory post hoc analysis of a pilot trial to explore the impact of 20 weeks of semaglutide use on bone density and turnover in older adults with overweight or obesity
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Retatrutide might fit non-diabetic adults with obesity whove failed other weight loss efforts
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highlighted the importance of CYP2D6 genotype in determining therapeutic efficacy, noting that poor metabolizers may derive less benefit from tamoxifen due to suboptimal endoxifen levels
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