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As of 1 January 2021, M2.2 (Intravenous infusions and/or injections of more than a total of 100 mL per 12-hour period) have now been classified as a Specified Method based on the newly introduced Article 4.2.2 in the 2021 Code, that makes it possible to identify a Prohibited Method as Specified

The Journal of Organic Chemistry, 85 (3), 1764-1768

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Moreover, patients and their families do not always understand the significance of their symptoms, especially with hypomanic or manic symptoms

Additionally, the powder has a distinctive odor that might be off-putting for some users