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Clinicians prescribe Zepbound for chronic weight management in adults with obesity (a BMI of 30+) or with excess weight (a BMI of 27+) and at least one weight-related health condition, such as type 2 diabetes, high blood pressure, or cardiovascular disease

and Olorofim (F901318), a broad-spectrum antifungal agent with fungal-specific inhibition (Maertens et al., 2025)

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In order to prevent degradation by DPP-4, scientists swapped the alanine at the inactivation site with a glycine