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Sakaue, T
AMPK, mTOR, and TFEB), the ultimate benefit hinges on the restoration of selective autophagic flux (117)
A dose escalation period would still be necessary
What the Evidence Actually Shows Being transparent about the evidence tier matters here more than for almost any other peptide, because the hype has outrun the approval timeline
Supporting this, in a phase 2a trial in people with MASLD, the dual GLP-1/GCG agonist efinopegdutide (10 mg) reduced liver fat by 72.7%, compared to 42.3% with semaglutide (1 mg) despite similar WLindicating potential weight-independent effects of GCG on hepatic steatosis [40]
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