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Now it seems oral small-molecule GLP-1s also dial back eating for pleasure by engaging a brain reward circuit. Given the effect of these drugs on eating for pleasure, future studies could explore whether small-molecule GLP-1s can also suppress cravings for other addictive substances

It is not established whether enough peptide survives first-pass absorption to produce meaningful systemic plasma concentrations for non-gastrointestinal targets

References: [1] FDA clarifies policies for compounders as national GLP-1 supply begins to stabilize (Accessed August 2025)

Vitamin H stands for "haar" and "haut"

None of this argues that every clinic should offer every compound