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The most common of them include Cu 2+ /Zn 2+ superoxide dismutase 1 ( SOD1 ), TAR DNA-binding protein 43 ( TARDBP) , fused in Sarcom a ( FUS ) , and chromosome 9 open reading frame 72 ( C9orf72) genes, involved in protein homeostasis and RNA metabolism [72,73,74,75]
Liang R, Ghaffari S (2014) Stem cells, redox signaling, and stem cell aging
They start as macules and target-like lesions with erythema and dark necrotic centers and develop into vesicles, erosions, or ulcerations with epidermal detachment
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