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FOXO4-DRI acts as a competitive inhibitor of this interaction binding directly to the transactivation domain 2 (TAD2) of p53, displacing FOXO4, and allowing phosphorylated p53 to be exported from the nucleus and directed to mitochondria, where it activates BAX, triggers caspase-3 cleavage (via the p53/BCL-2/Caspase-3 signalling pathway), and drives cell-intrinsic apoptosis
doi:10.1371/journal.ppat.1011536 72
This article will discuss about it and whether those with high blood pressure should use it
Condensed Matter : an Institute of Physics Journal, 29 (20), Article 203002
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