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Mayo Clin Proc 2013 , 88 , 544551 [6] Hroudov, J

As the disease progresses, additional brain regions involved in higher cognitive functions are affected, leading to more widespread cognitive and behavioral impairments ( 4 Biochemical and molecular mechanisms in PD Parkinsons disease is a chronic neurodegenerative disorder that is also progressive, similar to AD, and mainly affects the motor system, though non-motor symptoms are also prevalent

they are clinically indicated only for documented deficiency or malabsorption conditions

The mechanism involves inhibition of catechol-O-methyltransferase (COMT), which extends norepinephrine activity and slightly increases metabolic rate

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