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Nausea may persist as a background sensation rather than acute episodes, and some patients experience appetite loss so complete that eating feels like an obligation rather than a pleasure

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The authors noted that the effect sizes were meaningful but modest, and that strain specificity was a significant factor in determining outcomes

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Tirzepatide Safety Profile in Hypertensive Patients The SURMOUNT clinical trial program, which evaluated tirzepatide in over 4,500 participants, included many patients with existing hypertension taking concurrent medications