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BohneLJJansenHJDoreyTWDanielIMJamiesonKLBelkeDDet alGlucagon-like peptide-1 protects against atrial fibrillation and atrial remodeling in type 2 diabetic mice

The slowing of gastric motility is dose-dependent and represents both a therapeutic benefit and a potential source of gastrointestinal adverse effects

Our ISPOR poster aimed to address this gap

They used propensity score weighting to mitigate the imbalance among covariates between the groups

The inter-organelle complex formed by endosomal GLP-1R, ER VAPB and SPHKAP triggers a pool of ERMCS-localised cAMP/PKA signalling which leads to the phosphorylation of the mitochondrial contact site and cristae organising system (MICOS) complex component MIC19 and is accompanied by mitochondrial remodelling and modulation of mitochondrial function, with important consequences for -cell function and survival to oxidative stress