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The methylcobalamin component is generally safe in renal impairment, though accumulation of cobalt has been reported in patients with severe renal dysfunction receiving high doses of vitamin B12
This indicates that some potential confounders were either not consistently reported across studies or could not be adequately adjusted for in this meta-analysis
Ophthalmology 120 , 949955 (2013)
And its here where the concept of nasally administering BPC-157 attracted the attention of curious biohackers
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