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Headache has been mentioned by some users, particularly at higher doses

It has been widely studied in preclinical models for its potential to support tissue regeneration , angiogenesis , and inflammation modulation

For many patients, gastrointestinal side effects are most prominent during the first few weeks of treatment or when the dosage is increased

"Their main side effects are usually nausea and vomiting." In TRIUMPH-2, up to 11.6 percent of participants using retatrutide stopped the drug before the end of the trial due to side effects, compared with 4.9 percent of the placebo group

doi: 10.1210/clinem/dgz140 174 Ten KulveJSVeltmanDJVan BloemendaalLGrootPFCRuhHGBarkhofFet al