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These trials tracked numerous safety parameters and laboratory values, but vitamin b12 levels were not routinely monitored or reported in the published results

These are the mechanisms of healing

This syndrome has been reported to be more likely if the patient has abnormal kidney function.9 Although there is some significant debate on this point10, it is generally agreed that patients with abnormal kidney function should start allopurinol at low doses and build up, to ensure that the allopurinol is effectively excreted

Clinicians need to assess both conditions because the presence of depression can shape treatment priorities, medication choices, and the sequencing of psychotherapy

Presented for research literature review only Yanamoto K et al