Again, whether this is a process which is regulated is unknown, but it may help to explain why pharmacological use of DPP-4 inhibitors is generally not associated with weight loss (the appetite suppressive effects of increased intact GLP-1 levels being counter-balanced by the loss of the anorectic effects of PYY 3-36)
Retrieved April 20, 2026
That is not unique to GLP-1s
To minimize gastrointestinal side effects, clinicians start semaglutide at a low dose and titrate slowly, maintaining stable levothyroxine dosing until weight stabilizes
Given that obesity and hypertension frequently coexist and together substantially increase cardiovascular and kidney risk, these findings support obesity treatment as an important component of blood pressure management and cardiovascular risk reduction, said lead researcher Marcel Muskiet, MD, PhD, an internist, endocrinologist, and vascular medicine specialist in the Department of Medicine at Leiden University Medical Center (LUMC) in the Netherlands