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Semaglutide works through several mechanisms in the body, which make it effective for controlling blood sugar and supporting weight loss: Stimulates Insulin Release: Semaglutide encourages the pancreas to release insulin when blood sugar levels are high, helping to bring blood sugar levels back to a normal range

On the other hand, a Japanese single-center, open-label trial compared sitagliptin at suboptimal dosage with glimepiride in a cohort of 20 diabetic patients with ultrasound evidence of fatty liver: after 24 weeks of treatment, in the sitagliptin group but not in the glimepiride group, there was a significant reduction in intrahepatic lipid content and total body fat mass on H-MRS and DEXA despite a similar decrease in HbA1c [92]

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Microdosing: an alternative dosing approach Not everyone follows the standard escalation charts