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The most common clinical manifestations are dermatological, cardiac eg complete heart block, and haematological eg thrombocytopenia Prognosis for both mother and child are best when SLE is quiescent for at least six months before the pregnancy and when the mothers underlying renal function is stable and normal or near normal The Antiphospholipid syndrome The Antiphospholipid syndrome consists of persistently positive APL antibodies (two tests carried out 12 weeks apart) associated with arterial / venous thrombosis and / or adverse outcomes in pregnancy (mother or foetus) The Antiphospholipid syndrome occurs in isolation (primary APL syndrome) in more than 50% of patients, but it can be associated with autoimmune disease and other conditions (secondary APL syndrome)

However, these Tregs exhibited increased expression of IL-17a and Rort (Figure 3, N and O), markers associated with Th17 cells rather than the immunosuppressive Tregs This dysfunctional Treg phenotype aligns with the chronic, low-grade inflammatory state observed in the eWAT of Bbs5 / mice

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