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Knudsen is a scientist at the Danish drug maker Novo Nordisk, which harnessed insights by Habener and Mojsov to create the blockbuster drugs Ozempic for diabetes and Wegovy for obesity
It tends to concentrate around the midsection, comes with increased cravings and hunger, and is accompanied by other symptoms like sleep disruption and mood changes that make weight management even harder
Discussion We investigated the effect of liraglutide, a GLP-1 receptor agonist, in two mouse models which recapitulate some features of ALS pathophysiology and found no evidence that disease progression was altered at the behavioural or pathological level
We're throwing all that potential data away that could be used to actually identify real safety and evidence signals
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