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The study by Honda et al., conducted in 2017, was an open-label, single-arm, multicentre pilot study that evaluated the therapeutic effect of oral glutathione administration (300 mg/day) in patients with NAFLD through the evolution of biochemical indices (ALT) and liver fat levels assessed by VCTE (79)

Based on modern diagnostic criteria, this combination of symptoms could now be broadly classified as functional dyspepsia, which is often associated with gastric hypoacidity (86)

Am J Prev Med

This suggests that TJ dysfunction is an early event in the pathophysiology of hypertension, potentially facilitating subsequent vascular damage