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Iron (Fe 2+ ) derived from hemoglobin metabolism and immune responses, implicated in early ALS pathogenesis via oxidative stress, contributes to motor neuron damage, exacerbating BBB permeability changes [244, 245]
Loop diuretics are available via oral or IV routes, and furosemide, torsemide, and bumetanide are common forms (3)
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2017 31:1_supplement, 802.5-802.5 [13] Raghubeer S, Matsha TE
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