At a glance Origin: Gastric peptide
The observed excellent safety profile, along with the positive results presented herein, support further evaluation of ARA 290 as a disease modifying agent in subjects with painful diabetic neuropathy
Importantly, AOD-9604 did not produce any of the adverse effects associated with growth hormone therapy, including glucose intolerance, insulin resistance, edema, joint pain, or tissue growth abnormalities
They don't want a system, a layered system
Upon depolarization of astrocytes, molecules such as AQP4 that normally localize in endfoot membranes are redistributed to non-endfoot membranes, thereby compromising AQP4 function 24