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Lilly, for instance, already markets tirzepatide and is also banking on orforglipron, a once-daily small-molecule GLP-1 agonist that can be taken as a pill
The highest dose led to a 14.5% reduction in body weight by day 85, while the placebo group experienced a 1.5% weight gain
Others experience sulfur burps from day one that persist for several weeks before gradually improving
Signs of dehydration (reduced urination, dizziness, extreme thirst) from persistent vomiting or diarrhea require prompt medical attention due to risk of acute kidney injury
Combined with adequate protein intake (widely recommended at 1.2-1.6g per kg of body weight during GLP-1 protocols) and resistance training, the higher dose ranges may actually preserve lean mass better than lower doses, because the energy deficit is being met predominantly through fat oxidation rather than muscle catabolism
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