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Receptor activation Despite the existence of unique structural features among the ligand-binding pockets of GIPR, GLP-1R and GCGR, both tirzepatide and peptide 20 triggered receptor conformational changes similar to that induced by GLP-1 or GCG 4,27 and distinct from the inactive or apo GLP-1R and GCGR structures (Supplementary Fig
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It has even been posited as a prospective alternative to existing ED drugs like PDE5 inhibitors [7]
Bain SC, Hansen BB, Hunt B, Chubb B, Valentine WL
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