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It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)

Other lifestyle changes to alleviate diarrhea can include: Eating smaller, more frequent meals Get plenty of fluids Replenish electrolytes with broths and sports drinks 3

These inform clinical risk assessment but do not automatically confer eligibility for drug treatment

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This specificity supports the interpretation that GLP-1 receptor agonists selectively target alcohol-related subjective effects