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5-Amino-1MQ works by precisely blocking the catalytic pocket of the NNMT enzyme
This misunderstands basic receptor biology
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It was originally studied in the context of gastrointestinal healing, where the parent protein appears to play a role in protecting the gut lining
Funding This work was supported by grants from the National Natural Science Foundation of China (NSFC Numbers 81672800, 81603009, 81673020, 81802632, and 82173830), Natural Science Foundation of Shaanxi (2020JQ-445), and the Key Research and Development Program of Shaanxi Province (2021SF-207, 2021SF-223, and 2022ZDLSF05-19)
