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The ED 50 for this effect is 0.3840 ng/mL, corresponding to a specific activity is 2.6010 6 units/mg
In a Phase 2 clinical trial published in 2023 in the New England Journal of Medicine (Jastreboff et al.), participants receiving the highest dose of retatrutide lost up to approximately 24% of their body weight over 48 weeks a notably greater reduction than observed with currently approved agents
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