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Hemoglobin and iron released from hematomas activate microglia, leading to elevated inflammatory cytokines and mediators (193)

Although current evidence supports broad applicability across BMI, diabetes status, and fibrosis stages F2-F3, subgroup analyses suggest attenuated responses in non-obese patients and in certain ethnic groups (Hispanic patients in ESSENCE), emphasizing the need for precision medicine approaches incorporating anthropometric, genetic (e.g., PNPLA3, HSD17B13), and metabolic profiling

171,172 The anti-inflammatory and antioxidant properties of GLP-1 RAs contribute to maximizing the advantages of a better metabolic condition

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Freezing destroys the peptide structure irreversibly