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Also provides route for immune cell and stem cell recruitment

Concerning activating Met kinase domain mutations, Park and Di Renzo and Lee and Aebersold (Park et al., 1999

These effects are metabolically important because redox overload impairs mitochondrial respiration, accelerates BBB failure, and promotes PARP-1-dependent NAD + depletion [7,8,9, 15]

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Whereas the AP lies outside the bloodbrain barrier and has a high density of Gipr -expressing cells, most of which are GABAergic, many Gipr -expressing neurones in the hypothalamus have their cell bodies behind the bloodbrain barrier and include both glutamatergic and GABAergic neurons 16