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The trial confirmed the non-inferiority, but not superiority, of once weekly treatment with 2 mg of the long-acting extended release exenatide (80)
This structural feature contributes to orforglipron's selectivity for the GLP-1 receptor over other incretin receptors, a property that distinguishes it from multi-receptor agonists like tirzepatide and retatrutide
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People without type 2 diabetes, on the other hand, lost about 6% of their body weight in the same time period
Most users are started on a low dose that increases gradually to help minimize side effects
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