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This side effect has not been reported at similar rates with semaglutide or tirzepatide and appears to be related to the glucagon receptor activation component unique to retatrutide
Retrieved 2026-07-26
The active ingredients, semaglutide and tirzepatide, are FDA-approved in commercial formulations such as Wegovy, Ozempic, Mounjaro, and Zepbound
The result is skin that appears looser, less elastic, and sometimes prematurely aged even in younger patients
Also, avoid drinking too much alcohol, which can irritate your stomach, increase the risk of pancreatitis and affect blood sugar levels
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