Most common side effects include mild nausea, vomiting, constipation, and fatigue during the first 24 weeks
Various signals, including endoplasmic reticulum (ER) and oxidative stress and viral infection, activate ChaC1 promoters in different cell types, cellular processes and diseases through the unfolded protein response (UPR) (12,48,52)
2B, 5B, Supplemental Fig
Behavioural support such as keeping a food diary, setting realistic weekly goals, or accessing NHS weight management programmes can also significantly improve long-term adherence
Understanding how these medications work, who can access them, and what realistic outcomes to expect is essential for anyone considering GLP-1 therapy for weight management