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While the rigorous study confirmed that high-dose CoQ10 was entirely safe and well-tolerated, it did not demonstrate a statistically significant reduction in overall symptom severity compared to the placebo over the 6-week intervention periods

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Monitoring & adjustment : Periodic labs (micronutrients, metabolic markers, lean mass, bone density if relevant), and adjust supplements as needed under provider supervision

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Proton pump inhibitors and H2 receptor antagonists can reduce the absorption of dietary vitamin B12 by decreasing gastric acid production