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Common: nausea (especially during dose increasesusually mild and transient), constipation or diarrhea, occasional vomiting, fatigue in first weeks, decreased appetite (the desired effect, but worth noting)
Notably, over the subsequent 6 days, we observed a sustained body-weight-lowering effect after infusion of GLP-1MK-801, but not semaglutide, suggesting that the targeted inhibition of NMDA receptors in GLP-1 receptor-positive neurons might promote sustained changes to the defended level of adiposity
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This study has multiple limitations
Consistently, subsequent studies have further supported the pivotal roles of Hsp90 and AR signaling in regulating spermatogenic homeostasis and preserving male fertility (Tang et al., 2021)
