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Changes leading to increased distribution of MDM2 to the cell nucleus to inactivate p53 may contribute with a growth advantage for the tumour cells by upregulating the IGF-1R
The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice
It is not a safety assessment, it says nothing about suitability for any use in humans or animals, and it does not become a safety claim by being a large number
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