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The major problem with oral Glutathione is its low bioavailability and higher degradation rate, resulting in lower plasma levels of Glutathione

A 12-week facial cream study enrolled 71 women with mild to advanced photoaging and documented increased skin density and thickness, reduced laxity, improved clarity, and reduced fine line depth

Additionally, erythrocytes utilize the reactions of the PPP to generate large amounts of NADPH used in the reduction of glutathione (see below)

The proposed mechanism involves Epithalon's interaction with pinealocyte transcriptional machinery governing the rate-limiting enzymes in the melatonin synthesis pathway: arylalkylamine N-acetyltransferase (AANAT) and hydroxyindole-O-methyltransferase (HIOMT)