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Unlike native GLP-1, GLP1-S has been structurally modified with amino acid substitutions and a fatty acid side chain, which promotes albumin binding
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Moreover, reducing tumor lactate levels inhibits Kla and disrupts the lactate metabolic balance in the TME, representing a promising cancer treatment option that has already been implemented in several preclinical and clinical trials
Theres a lot of noise around protein requirements, but the science is pretty clear
Insulin dose reduction of 20 to 50% at triple agonist initiation is consistent with the approach used in tirzepatide trials: the SURPASS-5 trial (N=475) reduced insulin glargine by 20% at tirzepatide initiation, which reduced hypoglycemia without sacrificing glycemic control
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