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There is also some evidence that these drugs can alter the gut microbiome (the community of bacteria in your intestines), which might have subtle effects on nutrient metabolism
The authors thank Frank Kirchhoff for NG2-Cre mice, Akiko Nishiyama and Dirk Dietrich for NG2-dsRed mice, Andrew Tinker for Kir6.1 flx/flx mice, Elisa Avolio for providing human pericyte culture, David Hodson and Johannes Broichhagen for providing Luxendin555 probe, Thomas Kampourakis for suggesting the use of Mavacamten, Stuart Martin for genotyping, and Wolfgang Langhans, Alice Adriaenssens and Sergey Kandabarau for advice during this work
Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, Kalluri R
Because there is no effect using the tail flick assay is not evidence that PEA is ineffective as an analgesic
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