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The reduced availability of these medications, combined with their high cost, has led many patients to seek alternative ways to obtain them, including compounded medications that may not offer the same potency or safety profile as approved drugs

The initial dose for many patients is 2.5 mg once weekly, which is often increased over time based on tolerance and treatment goals

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This clinical trial followed 40 participants in an inpatient facility for opioid use disorder (OUD) who reported an average of a 40% reduction in opioid cravings

During dose escalation The transition from one dose to the next is when side effects are most intense