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However, approximately half of the patients undergoing endocrine therapy suffer relapses, including mutations in the ER coding gene ESR1 , especially the L536Q and Y537S mutations [6], which present a significant clinical challenge

In summary, the hyperglycemic state inherent to diabetes leads to ECD and inflammatory responses that persist even after normoglycemia restoration, due to epigenetic modifications [175]

This microbial shift enhanced the activity of group 3 innate lymphoid cells (ILC3s), thereby promoting anti-inflammatory cytokines IL-22 and IL-10 (Sun et al., 2024)

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*Correspondence: Yanning Chen, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers