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Placenta contained low but detectable activity of gamma-butyrobetaine dioxygenase
This reduction leads to the upregulation of Yes-associated protein 1/WW-domain-containing transcription regulator 1 (YAP/TAZ) and subsequently enhances the transcriptional activity of associated domain (TEAD1-4) and the forkhead box C2 (FOXC2), which regulate the expression of GLUT3 and lncRNA breast cancer anti-estrogen resistance 4 (BCAR4) [162, 163]
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Diagnosing Vitamin B12 Deficiency in the UK In the UK, diagnosis of vitamin B12 deficiency follows a systematic approach aligned with NICE and British Society for Haematology guidelines
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