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Despite the added testosterone boost, a guy can feel more wiped out early on even when his bloodwork shows hes headed in the right direction
That overlap is the core pharmacological reason combining them offers limited additive benefit and meaningful additive risk
PMC 3920715
Although the hypotensive effect of GLP-1 RAs seems to be manifested by BW losing, other mechanisms not related to BW might be implied by the mediation meta-analysis, which suggests an existence of BW-independent hypotensive effect of GLP-1 RA, along with the clinical evidence of weak or no correlations, and difference in time course between BP lowering and BW reducing effects
Tirzepatide is administered as a once-weekly subcutaneous injection, with dosing typically initiated at 2.5 mg for 4 weeks (a non-therapeutic initiation dose to improve tolerability), then increased every 4 weeks to reach a therapeutic dose of 5-15 mg weekly based on response and tolerability
