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Dual-action medications, such as tirzepatide, target both GIP and GLP-1 pathways

None of the trials reported a meaningful impact on discontinuation rates due to diarrhoea, reflux, or dyspepsia

Retatrutide for Metabolic Diseases Retatrutide shows potential benefits for individuals with: Obesity and severe obesity Insulin resistance Prediabetes and metabolic syndrome Type 2 diabetes Fatty liver associated with metabolic dysfunction Its triple-agonist profile allows simultaneous intervention across the major biological drivers of metabolic disease

Heart failure was not clearly defined in trials protocols, left ventricular ejection fraction was reported only in EXSCEL trial and in 4 trials heart failure functional class was defined

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