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During spermatid development and sperm maturation, progressive morphological abnormalities and motility decline under increasing doses, with partial recovery at 60 mg/kg but persistent impairment at 120 mg/kg, were reported by Chang et al
These findings establish ATM modulation as a strategic therapeutic axis in BBRs anti-obesity pharmacology [182]
The eGFR value is expressed in units of mL/min/1.73 m 2
It should be discontinued if pregnancy occurs and is not recommended during pregnancy or breastfeeding
Average weight loss: 15-20% of body weight over 68 weeks (with diet/exercise)
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