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Although no diagnostic guidelines exist specifically for GLP-1-related constipation, standard tests such as anorectal manometry and the balloon expulsion test can help identify patients who may benefit from this therapy

This approach is not validated in clinical trials but has theoretical merit for people with high GI sensitivity

It's highly inflammatory

Both medication classes can affect appetite, heart rate, and blood pressure, so regular cardiovascular assessment and monitoring of nutritional adequacy are essential under specialist supervision