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Treatment of HFpEF beyond the SGLT2-Is: Does the addition of GLP-1 RA improve cardiometabolic risk and outcomes in diabetic patients

Remarkably safe profile: animal studies found no lethal dose even at extremely high doses

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In contrast, in the absence of G protein coupling, the binding of peptide 5 promotes a rigidly outward shift of the intracellular tip of TM6 of GLP-1R by 12.1 without a sharp kink, 34 thereby creating an intracellular crevice for G protein coupling