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For that, the -glutamate-cysteine ligase (GshA) condenses the carboxyl group at the -position of glutamate with the amino group of cysteine, creating the dipeptide -glutamyl-cysteine

It is also related to better glycemic control and lower hypoglycemia

While analyses restricted to participants with established cardiovascular disease yielded MACE results that were directionally consistent with the overall analysis, conclusions are limited because subgroup estimates were based on trial-level reporting rather than individual participant data, and included studies continued to differ in patient characteristics, definitions of established cardiovascular disease, background therapies, and trial era

Side Effects: Common Side Effects: Nausea, vomiting, diarrhoea, constipation and abdominal discomfort are common, particularly in the early weeks and after each dose increase

It is not known whether oral lipoic acid supplementation can slow cognitive decline related to aging or pathological conditions in humans