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New frontiers in obesity treatment: GLP-1 and nascent nutrient-stimulated hormone-based therapeutics
For the research context it expanded the perspective from pure longevity to specific clinical indications , especially neurodegenerative diseases, where mitochondrial dysfunction and NAD+ deficit play a central role
GLP-1R alone, as activated by semaglutide, primarily signals through Gs-cAMP and PI3K pathways in beta-cell lines
Astrocyte-neuron lactate shuttle plays a pivotal role in sensory-based neuroprotection in a rat model of permanent middle cerebral artery occlusion
Results As shown in figure 1, exercise decreased all antioxidant enzymes studied
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