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Foundayo (Orforglipron) As the latest GLP-1 medication approved by the FDA in April 2026, Foundayo offers daily dosing flexibility, allowing intake at any time, with or without meals

These agents offer broad clinical utility beyond glucose lowering by mimicking the pleiotropic hormonal responses observed after bariatric surgery

GLP-1 is rapidly cleaved by the widely expressed dipeptidyl-peptidase-IV (DPP-IV), which removes two N-terminal amino acids, resulting in GLP-1(9-36) with little glucoregulatory properties but with potential cardiovascular effects [18]

, derived from measured hemoglobin + hematocrit, is practical to calculate from a single blood draw and trend over time